Resource Type

Journal Article 34

Year

2022 4

2021 4

2020 2

2019 1

2018 2

2017 4

2016 2

2015 1

2012 1

2010 1

2009 1

2008 2

2007 6

2004 1

open ︾

Keywords

Philadelphia chromosome 2

positive feedback 2

21-gene assay 1

Escherichia coli 1

Campylobacter 1

Candida 1

blaNDM-5 1

Antimicrobial resistance transmission 1

Beamforming 1

CALLG2008 1

CFD simulation 1

Carbapenem resistance 1

Chinese corporate governance 1

Ciprofloxacin 1

Common Lyapunov function 1

Composition profile 1

Coupling synchronization 1

Cryptococcus gattii 1

Cryptococcus neoformans 1

open ︾

Search scope:

排序： Display mode:

EFFECTS OF TRANSPORT STRESS ON THE INTESTINES INVOLVING NEURONAL NITRIC OXIDE SYNTHASE

Frontiers of Agricultural Science and Engineering   Pages 285-295 doi: 10.15302/J-FASE-2022469

Abstract:

● Transport stress declined the level of leukocytes including lymphocytes in rat serum.

Keywords： intestine     nNOS     nNOS-positive neurons     transport stress    

HTML PDF Collect

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 418-422 doi: 10.1007/s11684-007-0082-7

Abstract: The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion wereability of learning and memorizing, Nissl staining was used to count the average number of survived neuronsNissl staining results showed a significant reduction in the number of pyramidal neurons in hippocampalpretreatment can improve the spatial learning and memorizing function through protection to hippocampal neurons
HTML PDF Collect

Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with

Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 330-335 doi: 10.1007/s11684-009-0051-4

Abstract: This study aimed to investigate the protective effect of nicotine on dopaminergic neurons and its mechanismsSimultaneously, TH-positive ( < 0.01) neurons and GABA-positive ( < 0.05) neurons in the nicotineNicotine has protective effects on the γ-aminobutyric acid neurons and dopaminergic neurons in the

Keywords： Parkinson disease     nicotine     dopaminergic neuron     gamma-aminobutyric acid neuron    

HTML PDF Collect

Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 223-228 doi: 10.1007/s11684-017-0517-8

Abstract: triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positiveClinico-pathological data of HSIL patients with positive margin by conization were retrospectively collectedNearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgicalspecimens, and those with multiple positive margins may consider re-conization or re-assessment.

Keywords： cervical high-grade squamous intraepithelial lesion     conization     positive surgical margin     hysterectomy    

HTML PDF Collect

NO conversion by positive streamer discharge—effects of gas compositions and reaction conditions

HE Wei, ZHU Tianle, LI Jing

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2,   Pages 153-158 doi: 10.1007/s11783-007-0027-z

Abstract: The effects of gas compositions and reaction conditions on NO conversion by positive streamer discharge

Keywords： conversion     streamer discharge     wheel-cylinder     positive streamer    

HTML PDF Collect

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 264-268 doi: 10.1007/s11684-008-0050-x

Abstract: procedure of brainstem slices and the spontaneous firing properties of rat medial vestibular nucleus (MVN) neuronsBy infrared differential interference contrast technique, neurons of rat MVN were visualized directlyFiring activities of MVN neurons were recorded by the whole-cell patch clamp technique in artificialafter-hyperpolarization potential (AHP), and the neurons with biphasic AHP.The resting membrane potential (RMP), input resistance (Rin) and membrane capacitance (Cm) of neurons

Keywords： resistance     infrared     infrared videomicroscopy     depressive     after-hyperpolarization potential    

HTML PDF Collect

To Hold the Economical Time of Biology，to Practicea Positive View of Happiness

Gan Ziheng

Strategic Study of CAE 2007, Volume 9, Issue 2,   Pages 5-11

Abstract: proposition, definition, classification and characteristic of biological economy, also, the importance of positiveIt also discusses which views of happiness should be recommended and how to practice a positive view

Keywords： biological economy     happiness     positive view of happiness    

HTML PDF Collect

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

HTML PDF Collect

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: Brain development requires a delicate balance between self-renewal and differentiation in neural stem cells (NSC), which rely on the precise regulation of gene expression. Ten-eleven translocation 2 (TET2) modulates gene expression by the hydroxymethylation of 5-methylcytosine in DNA as an important epigenetic factor and participates in the neuronal differentiation. Yet, the regulation of TET2 in the process of neuronal differentiation remains unknown. Here, the protein level of TET2 was reduced by the ubiquitin-proteasome pathway during NSC differentiation, in contrast to mRNA level. We identified that TET2 physically interacts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself. The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiation. The silencing of the core subunits of the GID complex, including WDR26 and ARMC8, attenuated the ubiquitination and degradation of TET2, increased the global 5-hydroxymethylcytosine levels, and promoted the differentiation of the NSC. TET2 level increased in the brain of the Wdr26+/− mice. Our results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates NSC differentiation, and represents a novel regulatory mechanism involved in brain development.

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

HTML PDF Collect

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 440-444 doi: 10.1007/s11684-017-0523-x

Abstract:

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguishand BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive

Keywords： Philadelphia chromosome     acute myeloid leukemia     mass     osteolysis     positron emission tomography    

HTML PDF Collect

of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 229-238 doi: 10.1007/s11684-017-0506-y

Abstract: We retrospectively analyzed 153 newly diagnosed adult patients with Philadelphia chromosome (Ph)-positiveAll these results suggested that imatinib plus CALLG2008 was an effective protocol for Ph-positive ALL

Keywords： Philadelphia chromosome     acute lymphoblastic leukemia     imatinib     CALLG2008    

HTML PDF Collect

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

HTML PDF Collect

Phase synchronization and energy balance between neurons Research Article

Ying XIE, Zhao YAO, Jun MA

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 9,   Pages 1407-1420 doi: 10.1631/FITEE.2100563

Abstract: We propose two kinds of criteria to discuss the enhancement of synapse connections to neurons.for neurons, and the realization of synchronization is helpful in maintaining energy balance betweenneurons.When two neurons become non-identical, phase synchronization can be controlled during the activationof synapse connections to neurons.

Keywords： Hamilton energy     Coupling synchronization     Synapse enhancement     Neural circuit    

HTML PDF Collect

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: Heterocyclic compound quinoline and its derivatives exist in natural compounds and have a broad spectrum of biological activity. They play an important role in the design of new structural entities for medical applications. Similarly, indoles and their derivatives are found widely in nature. Amino acids, alkaloids and auxin are all derivatives of indoles, as are dyes, and their condensation with aldehydes makes it easy to construct reaction sites for nucleophilic addition agents. In this work, we combine these two groups organically to construct a rapid response site (within 30 s) for H S, and at the same time, a ratiometric fluorescence response is presented throughout the process of H S detection. As such, the lower detection limit can reach 55.7 nmol/L for H S. In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous H S. Finally, this probe application was verified by imaging H S in nude mice.

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

HTML PDF Collect

Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid

Fernando F. Rivera, Berenice Miranda-Alcántara, Germán Orozco, Carlos Ponce de León, Luis F. Arenas

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 399-409 doi: 10.1007/s11705-020-1934-9

Abstract: local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive

Keywords： CFD simulation     porous media     porous electrode     pressure drop     redox flow battery    

HTML PDF Collect

Title Author Date Type Operation

EFFECTS OF TRANSPORT STRESS ON THE INTESTINES INVOLVING NEURONAL NITRIC OXIDE SYNTHASE

Journal Article

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Journal Article

Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with

Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,

Journal Article

Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Journal Article

NO conversion by positive streamer discharge—effects of gas compositions and reaction conditions

HE Wei, ZHU Tianle, LI Jing

Journal Article

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Journal Article

To Hold the Economical Time of Biology，to Practicea Positive View of Happiness

Gan Ziheng

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Journal Article

of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

Phase synchronization and energy balance between neurons

Ying XIE, Zhao YAO, Jun MA

Journal Article

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid

Fernando F. Rivera, Berenice Miranda-Alcántara, Germán Orozco, Carlos Ponce de León, Luis F. Arenas

Journal Article